本生醫暨半導體製程高分子材料實驗室致力於高分子化學與生醫材料的研究及應用，嘗試在各種機能性高分子合成及奈米載體設計及制作，並加入分子尺度的立體結構設計，探討材料與生物體之間的交互作用，並且改善藥物傳輸的效益與組織再生的結果。本實驗室也與其他學術界及醫學中心的合作相當密切，目前實驗室發展的方向主要有：目前研究方向包含聚乳酸立體複合材料、功能性幾丁聚醣奈米纖維、二氧化碳衍生聚碳酸酯等新穎生醫功能元件開發。
此外，我們亦將頂尖的高分子合成技術跨足至先進半導體領域，致力於開發應用於導向自組裝 (DSA) 的新型嵌段共聚物 (BCPs)。針對 Sub-10 nm 節點的微影製程需求，本實驗室採用無金屬殘留的可逆加成-斷裂鏈轉移 (RAFT) 聚合技術，精確合成具高交互作用參數 (高 χ 值) 與極低分散性 (PDI < 1.1) 的自主裝材料。此技術不僅突破了傳統 PS-b-PMMA 的解析度極限，有效避免相位錯位與缺陷，更完全符合 CMOS 製程對材料純淨度的嚴苛標準。
Prof. Chih-Kuang Chen’s lab is highly interdisciplinary and is committed to exploring novel functional polymeric materials to enable new schemes on manipulating and processing of biocompatible nanomaterials in nanomedicine and regenerative medicine applications. Some representatives of our scientific achievements toward “Next-Generation Therapeutics” The current research directions include:
(1) Polylactide (PLA) Stereocomplex Engineering: Development of PLA stereocomplexes and investigation on their stability and drug release behaviors.
(2) Chitosan (CS) Nanofibers: Fabrication of nanocapsule-in-nanofiber structures and their functional applications in diabetic wound healing.
(3) CO2-Derived Polycarbonates (PC): Synthesis of cationic polycarbonates via CO2 utilization for non-viral gene delivery systems.
(4) Smart Nanocarriers: Development of various methods to synthesize pH/redox dual-responsive micelles for precise cancer therapy.
(5) Semiconductor BCPs for Lithography: Utilizing metal-free RAFT polymerization to synthesize high-χ, ultra-low dispersity (PDI < 1.1) block copolymers for directed self-assembly (DSA), overcoming the resolution limits of conventional PS-b-PMMA to meet sub-10 nm CMOS purity standards.
We welcome all the potential new graduate students, undergraduate students.
If you are interested in joining our lab, please contact with Dr. Chen for the further information.
若對實驗室有任何問題或是想要加入本實驗室，歡迎聯絡我們！
實驗室/Lab (MOES building Room 5008)
學生辦公室/Student Office (MOES building Room 5018)
Prof. Chih-Kuang Chen (chihkuan@mail.nsysu.edu.tw )